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Synthese von N ‐Ethylguanosin‐5′‐carboxamid
Author(s) -
Jung KarlHeinz,
Schmidt Richard R.
Publication year - 1988
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198819881017
Subject(s) - chemistry , glycosyl , halide , cyanide , condensation , mercury (programming language) , catalysis , carboxamide , medicinal chemistry , nuclear magnetic resonance spectroscopy , nuclear chemistry , organic chemistry , physics , computer science , thermodynamics , programming language
Synthesis of N ‐Ethylguanosine‐5′‐carboxamide N ‐Ethylguanosine‐5′‐carboxamide ( 5 ) was prepared by condensation of O ‐benzoyl‐protected riburonic acid glycosyl halide 1 and N 2 ‐acetylguanine ( 2 ) with mercury( II ) cyanide as a catalyst. The N 7 ‐isomer, obtained as a byproduct, was separated by reversed‐phase medium‐pressure liquid chromatography. The structures were determined by NMR and UV spectroscopy.