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Zur Synthese von Benzoesäurederivaten aus 3‐Ethoxymethylen‐2,4‐alkandionen und Malonsäuredinitril
Author(s) -
Schmidt HansWerner,
Kores Margarete
Publication year - 1988
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198819881013
Subject(s) - malononitrile , chemistry , benzonitrile , nitrile , benzoic acid , hydrolysis , hydrochloride , organic chemistry , medicinal chemistry , catalysis
Synthesis of Benzoic Acid Derivatives from 3‐Ethoxymethylene‐2,4‐alkanediones and Malononitrile Reaction of the 3‐ethoxymethylene‐2,4‐alkanediones 1a – c with malononitrile ( 2 ) gives the benzonitrile derivatives 3a – c . Compounds 4a – d are obtained by acid or basic hydrolysis of the nitrile group of 3a – c , Sandmeyer reaction leads to the halogenated benzonitriles 5a – f . Compounds 6a, b are available from 3a and O ‐ethyl‐ and O ‐allylhydroxylamine hydrochloride.