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Steroids, XL. 15‐(hydroxymethyl)androstene and ‐estratriene derivatives
Author(s) -
Vincze Irén,
Somlai Csaba,
Schneider Gyula,
Dombi György
Publication year - 1988
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198819881007
Subject(s) - hydroxymethyl , chemistry , triol , fragmentation (computing) , stereochemistry , medicinal chemistry , organic chemistry , diol , computer science , operating system
15α‐Hydroxymethyl‐5‐androstene‐3β,16β,17β‐triol ( 5d ) and 16β‐hydroxy‐15α‐(hydroxymethyl)estratriene derivatives 9 were prepared from the corresponding 15‐hydroxymethylene‐16‐ketones 3 and 4 . The configurations of the chiral centers were determined by means of chemical transformations and on the basis of spectroscopic data. The D‐seco derivatives 6 and 8 were identified as the products of a fragmentation and a 1,3‐dicarbonyl fission, respectively.