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Asymmetric synthesis of carbacyclin precursors by Pauson‐Khand cyclization
Author(s) -
Mulzer Johann,
Graske KlausDieter,
Kirste Burkhard
Publication year - 1988
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198819880913
Subject(s) - chemistry , pauson–khand reaction , cobalt , stereochemistry , medicinal chemistry , organic chemistry , intramolecular force
The carbacyclin precursors 11, 17, 18 have been prepared from the en‐ynes 10, 15, 16 by cobalt‐mediated cyclization (Pauson‐Khand reaction) with varying degrees of diastereoselectivity.