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Glycosidation, IX. Synthesis of functionalised acetals for coupling with monoclonal antibodies and other biopolymers
Author(s) -
Tietze Lutz F.,
Goerlach Ada,
Beller Matthias
Publication year - 1988
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198819880612
Subject(s) - chemistry , trimethylsilyl , trimethylsilyl trifluoromethanesulfonate , moiety , acetal , trifluoromethanesulfonate , monoclonal antibody , glycoside , alcohol , catalysis , organic chemistry , combinatorial chemistry , antibody , immunology , biology
Abstract For coupling of acetal‐glycosides 3 and 4 of cytotoxic aldehydes with biopolymers for the selective treatment of cancer, acetals of type 5 or 6 , which bear a carboxylic ester function or an acylated amino group in the alcohol moiety, were prepared by reaction of aldehydes 7a–d and the trimethylsilyl ethers 8a–d in the presence of a catalytic amount of trimethylsilyl trifluoromethanesulfonate.