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Synthesis of oxaziridinylquinones and oxaziridinylazines as potential antitumor agents
Author(s) -
Mlochowski Jacek,
Kubicz Elżbieta,
Kloc Krystian,
Mordarski Marian,
Peczyńska Wanda,
Syper Ludwik
Publication year - 1988
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198819880515
Subject(s) - chemistry , aldimine , combinatorial chemistry , stereochemistry , organic chemistry , catalysis
1,4‐Benzoquinones, 1,4‐naphthoquinones, as well as pyridines and quinolines having 2‐alkyloxaziridinyl substituents were synthesized. The method involves formation of aldimines and their oxidation to oxaziridines. 1,4‐Dimethoxyarenes bearing oxaziridinyl substituents were converted into the corresponding quinones with silver(II) dipicolinate. Some of the oxaziridinylquinones and ‐azines exhibit activity against KB cells, and the structure‐activity relationship is discussed in terms of the current theory of biologically activated alkylating agents.