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Synthese von α‐ D ‐ glycero ‐ D ‐ galacto ‐2‐Octulonsäure und 5‐Acetamido‐5‐desoxy‐β‐ D ‐ erythro ‐ L ‐ gluco ‐2‐nonulonsäure
Author(s) -
Paulsen Hans,
Krogmann Christof,
Deessen Ulrich Von
Publication year - 1988
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198819880317
Subject(s) - chemistry , diastereomer , stereochemistry , hydroxylation , biochemistry , enzyme
Synthesis of α‐ D ‐ glycero ‐ D ‐ galacto ‐2‐Octulosonic Acid and 5‐Acetamido‐5‐deoxy‐β‐ D ‐ erythro ‐ L ‐ gluco ‐2‐nonulosonic Acid The osmium tetroxide hydroxylation of the unsaturated compounds 1 and 5 yields stereoselectively derivatives of α‐ D ‐ glycero ‐ D ‐ galacto ‐octulosonic acid and 5‐acetamido‐5‐deoxy‐β‐ D ‐ erythro ‐ L ‐ gluco ‐2‐nonulopyranosonic acid. Both compounds are derived from KDO and 5‐ N ‐acetylneuraminic acid and contain an additional equatorial hydroxyl group at C‐3.