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5‐Chloro‐3‐(2‐nitroethenyl)salicylic acid anilides and related substances, new polyactive biocides
Author(s) -
Asaad Fahmy M.,
Grant Nabil,
Latif Nazih
Publication year - 1988
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198819880214
Subject(s) - chemistry , nitromethane , salicylic acid , chloroform , alkali metal , chloride , condensation , organic chemistry , medicinal chemistry , biochemistry , physics , thermodynamics
5‐Chloro‐3‐formylsalicylic acid ( 1 ) is readily obtained by reaction of 5‐chlorosalicylic acid with chloroform in alkali. 1 condenses with nitromethane to give 5‐chloro‐3‐(2‐nitroethenyl)‐salicylic acid ( 2 ) which condenses with anilines through its chloride at low temperature to give the title anilides 4 . However, when the condensation is conducted at higher temperature, the corresponding azomethines 5 are produced. The latter are obtained also by treating 4 with anilines at higher temperature. The molluscicidal and fungicidal activities of the products are discussed.