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Synthesis of Linear Annulated Tricyclic Heterocycles Incorporating the Pyrazolo[3,4‐ d ]pyrimidine Skeleton
Author(s) -
Svêtlík Jan
Publication year - 1987
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198719870884
Subject(s) - chemistry , tricyclic , pyrimidine , thiazine , ring (chemistry) , stereochemistry , acetal , medicinal chemistry , organic chemistry
Pyrazolo[3,4‐ d ]thiazolo[3,2‐ a ]pyrimidine 3a, 5 and 6 , pyrazolo[3′,4′:4,5]pyrimido[2,1‐ b ][1,3]thiazine 3b , and pyrazolo‐[3′,4′:4,5]pyrimido[2,1‐ b ][1,3]thiazepine 3c representing novel heterocyclic systems were prepared by cyclization of 2,5‐dihydro‐6‐mercapto‐2‐methyl‐4 H ‐pyrazolo[3,4‐ d ]pyrimidin‐4‐ one ( 1 ) with dibromoalkanes and bromoacetaldehyde diethyl acetal.