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Synthese von 2,3‐Bis(ethoxycarbonyl)‐1 H ‐pyrrol‐1‐propionsäure‐ethylester
Author(s) -
Röder Erhard,
Wiedenfeld Helmut,
Bourauel Thomas
Publication year - 1987
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198719870883
Subject(s) - chemistry , pyrrole , dehydrogenation , medicinal chemistry , propionate , oxalate , alkylation , diethyl malonate , catalysis , organic chemistry
Synthesis of Ethyl 2,3‐Bis(ethoxycarbonyl)‐1 H ‐pyrrole‐1‐propionate Ethyl 2,3‐bis(ethoxycarbonyl)‐1 H ‐pyrrole‐1‐propionate ( 7 ) can easily be obtained in high yields from ethyl 4‐iodobutyrate ( 1 ) via reaction with dibenzylamine and diethyl oxalate, catalytic debenzylation to diethyl cis ‐2,3‐pyrrolidinedicarboxylate ( 5 ), subsequent dehydrogenation to diethyl 1 H ‐pyrrole‐2,3‐dicarboxylate ( 6 ), and further N ‐alkylation to the desired title compound 7 .