Synthese von 2,3‐Bis(ethoxycarbonyl)‐1 H ‐pyrrol‐1‐propionsäure‐ethylester | Zendy

Röder Erhard | Zendy; Wiedenfeld Helmut | Zendy; Bourauel Thomas | Zendy

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Synthese von 2,3‐Bis(ethoxycarbonyl)‐1 H ‐pyrrol‐1‐propionsäure‐ethylester

Author(s) -

Röder Erhard,

Wiedenfeld Helmut,

Bourauel Thomas

Publication year - 1987

Publication title -

liebigs annalen der chemie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 0170-2041

DOI - 10.1002/jlac.198719870883

Subject(s) - chemistry , pyrrole , dehydrogenation , medicinal chemistry , propionate , oxalate , alkylation , diethyl malonate , catalysis , organic chemistry

Synthesis of Ethyl 2,3‐Bis(ethoxycarbonyl)‐1 H ‐pyrrole‐1‐propionate Ethyl 2,3‐bis(ethoxycarbonyl)‐1 H ‐pyrrole‐1‐propionate ( 7 ) can easily be obtained in high yields from ethyl 4‐iodobutyrate ( 1 ) via reaction with dibenzylamine and diethyl oxalate, catalytic debenzylation to diethyl cis ‐2,3‐pyrrolidinedicarboxylate ( 5 ), subsequent dehydrogenation to diethyl 1 H ‐pyrrole‐2,3‐dicarboxylate ( 6 ), and further N ‐alkylation to the desired title compound 7 .

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