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A Convenient and Single‐Step Synthesis of Substituted 12 H ‐Quinoxalino‐[2,3‐ b ][1,4]benzothiazines and ‐benzoxazines
Author(s) -
Agarwal Nand L.,
Sharma Ashwani K.,
Jamwal Rajendra S.,
Atal Chand K.,
Torres Tomas
Publication year - 1987
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198719870849
Subject(s) - chemistry , dimethylformamide , base (topology) , solvent , medicinal chemistry , zinc , organic chemistry , combinatorial chemistry , mathematics , mathematical analysis
Cyclocondensation of 2,3‐dichloroquinoxaline ( 4 ) and the 2‐aminothiophenols 1a–h or their zinc mercaptides 3a–h in the presence of alkaline dimethylformamide or in acidic medium afforded the corresponding 12 H ‐quinoxalino[2,3‐ b ][1,4]benzothiazines 7a–h in excellent yields. Similarly, the reaction of 4 with substituted 2‐aminophenols 2 in the presence of base using dimethylformamide as solvent gave the 12 H ‐quinoxalino[2,3‐ b ][1,4]‐benzoxazines 7i–k . Acetyl derivatives of 7a–k were prepared.