Synthesis of New Xanthene Derivatives with Expected Antischistosomal Activity | Zendy

Zeid Ibrahim | Zendy; ElKousy Salah | Zendy; ElTorgoman Abdel Moneim | Zendy; Ismail Abdel Hamid | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of New Xanthene Derivatives with Expected Antischistosomal Activity

Author(s) -

Zeid Ibrahim,

ElKousy Salah,

ElTorgoman Abdel Moneim,

Ismail Abdel Hamid

Publication year - 1987

Publication title -

liebigs annalen der chemie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 0170-2041

DOI - 10.1002/jlac.198719870210

Subject(s) - chemistry , xanthene , phthalimide , succinimide , diazomethane , hydrolysis , derivative (finance) , pyrrolidine , medicinal chemistry , organic chemistry , combinatorial chemistry , financial economics , economics

N ‐(9 H ‐Xanthen‐9‐yl)succinimide ( 1 ) is prepared by the reaction of xanthene with N ‐bromosuccinimide. Hydrolysis of 1 with 5% NaOH yields 3‐[(9 H ‐xanthen‐9‐yl)aminocarbonyl]propionic acid ( 3a ). The corresponding methyl ester 3c is obtained from 3a by the action of diazomethane. The butanol derivative 4a can be obtained by reduction of 3a or 3c with LiAlH 4 . Treatment of 1 with LiAlH 4 yields the pyrrolidine derivative 5 . N ‐(9 H ‐Xanthen‐9‐yl)phthalimide ( 2 ) undergoes similar reactions like its analogue 1 .

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research