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A New, Convenient Synthesis of 1,6‐Diaryl‐2‐thioxoperhydro‐4‐pyrimidinones: Reaction of 3‐Phenyl‐2‐propenoyl Isothiocyanate With Aromatic and Heteroaromatic Amines
Author(s) -
Hafez Ebtisam Abdal Aziz,
Elmoghayar Mohamed Rifaat Hamza,
Ramiz Mahmoud Mohamed Mahfouz
Publication year - 1987
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198719870111
Subject(s) - chemistry , pyrimidinones , phenyl isothiocyanate , isothiocyanate , sodium ethoxide , medicinal chemistry , organic chemistry , allyl isothiocyanate , ethanol
The substitued thioureas 3a–h , prepared form 3‐phenyl‐2‐propenoyl isothiocyanate ( 1 ) and aromatic or heteroaromatic amines 2a–h , cyclize in the presence of sodium ethoxide to give the perhydropyrimidine derivatives 5a–c .