Synthesis of 5′‐[(3‐Aminooxypropyl)amino]‐5′‐deoxyadenosine

The synthesis of the title compound 2 is described. N ‐Alkylation of 5′‐amino‐5′‐deoxy‐2′,3′‐ O ‐(1‐methylethylidene)adenosine ( 3 ) with [(3‐iodopropoxy)methyl]benzene gave after debenzylation the 5′‐deoxyadenosine derivative 4b . After derivatization of the 5′‐NH, the terminal hydroxy group was reacted with triphenylphosphane, diethyl azodicarboxylate, and N ‐hydroxyphthalimide to yield a full protected derivative of 2 . Sequential deprotection (H 2 NNH 2 , then H 2 SO 4 ) afforded the target molecule 2 as its sesquisulfate salt.