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Phosphorus Pentoxide in Organic Synthesis, XVI. A One‐step Synthesis of 2‐Methyl‐ N 6 ‐aryladenines from 5‐Acetylamino‐1 H ‐imidazole‐4‐carboxamide Hydrochloride
Author(s) -
Andersen Knud Erik,
Pedersen Erik B.
Publication year - 1985
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198519850506
Subject(s) - chemistry , phosphorus pentoxide , hydrochloride , triethylamine , carboxamide , imidazole , medicinal chemistry , aniline , organic chemistry
5‐Amino‐1 H ‐imidazole‐4‐carboxamide hydrochloride has been converted into a series of 2‐methyl‐6‐(arylamino)purines 3 via 5‐acetylamino‐1 H ‐imidazole‐4‐carboxamide hydrochloride ( 1 ) which was heated with phosphorus pentoxide, triethylamine hydrochloride, and an appropriate substituted aniline at 180°C.
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