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Chemoselektive Fluoreszenzstudien am Subtilisin und “Thiosubtilisin”
Author(s) -
Flemming HansWolfram,
Horner Leopold
Publication year - 1985
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198519850221
Subject(s) - subtilisin , chemistry , fluorescence , serine , serine protease , stereochemistry , biochemistry , enzyme , protease , physics , quantum mechanics
Chemoselective Fluorescence Studies with Subtilisin and “Thiosubtilisin” The serine hydroxy group in the active site of subtilisin is selectively “phosphylated” 3) . This is demonstrated using the fluorescent phosphinic fluoride 1 . “Thiosubtilisin” does not react with 1 but with the SH‐selective and fluorescent vinyl sulfone 2 .
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