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Cyclit‐Reaktionen, IX. Synthese von 1 L ‐1‐Desoxy‐1‐ C ‐hydroxymethyl‐ myo ‐inosit und 1 L ‐1‐Desoxy‐1‐ C ‐hydroxymethyl‐ chiro ‐inosit
Author(s) -
Paulsen Hans,
Röben Wolfgang
Publication year - 1983
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198319830618
Subject(s) - chemistry , hydroxymethyl , cyclitol , stereochemistry , methylene , inositol , medicinal chemistry , biochemistry , receptor
Cyclitol Reactions, IX. – Synthesis of 1 L ‐1‐Deoxy‐1‐ C ‐hydroxymethyl‐ myo ‐inositol and 1 L ‐1‐Deoxy‐1‐ C ‐hydroxymethyl‐ chiro ‐inositol Hydroboration of the exo ‐methylene compound 3 with disiamylborane leads to the alcohols 4 and 6 . Removal of the protective groups results in the enantiomerically pure, branched‐chain (hydroxymethyl)inositols having 1 L ‐ myo configuration and 1 L ‐ chiro configuration, respectively.