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Preparation of 3,4‐Dihydroxy‐1‐benzeneethanol: A Reinvestigation
Author(s) -
Baraldi Pier Giovanni,
Simoni Daniele,
Manfredini Stefano,
Menziani Emilia
Publication year - 1983
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198319830417
Subject(s) - chemistry , phenol , organic chemistry , reduction (mathematics) , combinatorial chemistry , medicinal chemistry , stereochemistry , mathematics , geometry
A reinvestigation of the two known methods of preparation of the title compound 1 revealed that one of these leads to a mixture of 1 and 4‐[2‐(acetoxy)ethyl]‐1,2‐benzenediol ( 5 ). The other method yields only 2‐methoxy‐4‐(2‐phenylethyl)phenol ( 6 ). An unambiguous straightforward preparation of 1 by LiAlH 4 reduction of 3,4‐dihydroxy‐1‐benzeneacetic acid ( 8 ) is described.