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Aminierte Acetalglycoside als kompetitive Inhibitoren der α‐ D ‐Glucosidase aus Hefe
Author(s) -
BlancMuesser Michèle,
Defaye Jacques,
HüterPaulus Susanne,
Lehmann Jochen
Publication year - 1983
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198319830114
Subject(s) - yeast , chemistry , stereochemistry , acetal , biochemistry
Animated Acetal Glysocides as Competitive Inhibitors of α‐ D ‐Glucosidase from Yeast Previously synthesized [(S)‐2‐bromo‐1‐methoxyethyl] and [(R)‐2‐bromo‐1‐methoxyethyl] α‐ D ‐glucopyranoside ( 1a ) and ( 2a ), respectively, are suitable substrates for α‐glucosidase from yeast. Substitution of bromine in 1a and 2a for an amino group turns the substrates into the competitive inhibitors [(S)‐2‐amino‐1‐methoxyethyl] and [(R)‐2‐amino‐1‐methoxyethyl] α‐ D ‐glucopyranoside ( 1b ) and ( 2b ), respectively