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Notiz zur Darstellung N,N ‐disubstituierter aliphatischer Thiocarbonsäureamide, N ‐substituierter Thiolactame und aromatischer Thiocarbonsäureester
Author(s) -
Kantlehner Willi,
Haug Erwin,
Farkas Michael
Publication year - 1982
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198219820821
Subject(s) - chemistry , thiolysis , medicinal chemistry , hydrogen sulfide , dimethylformamide , organic chemistry , sulfur , polyphenol , proanthocyanidin , solvent , antioxidant
Note on the Preparation of N,N ‐Disubstituted Aliphatic Thiocarboxamides, N ‐Substituted Thiolactams, and Aromatic Thiocarboxylates Hydrogen sulfide reacts with the N,N ‐dimethylformamide acetal 1 to give N,N ‐(dimethyl)thioformamide ( 2a ). The thioamides 2a–e and the thiolactams 2f, g are prepared by thiolysis of the nitriles 3a–g . The action of hydrogen sulfide on nitriles 5a–f affords the O ‐ethyl thiocarboxylates 6a–f . The preparation of the nitriles 3g and 5a–f is described.