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Stereocontrolled Synthesis of the Insect Growth Regulators — Alkyl (2 E ,4 E )‐Dodecadienoates
Author(s) -
Nov´k Lajos,
Roh´ly J´nos,
Kolonits P´l,
Fekete Jenö,
Varjas Ĺszló,
Sźntay Csaba
Publication year - 1982
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198219820618
Subject(s) - chemistry , enol , stereoselectivity , lithium (medication) , alkyl , phosphate , condensation , organic chemistry , medicinal chemistry , catalysis , medicine , physics , thermodynamics , endocrinology
The title compounds 1 and 16 were synthesized by condensation of the dianions of β‐keto esters 5 and 11 with aldehydes 4 , and lithium dialkylcuprate addition to the enol acetate or enol phosphate of unsaturated β‐keto esters 8 and 15 . The (2 E ,4 E )‐dodecadienoate derivatives 1 and 16 were formed in a stereoselective manner.