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2‐Methylthio‐7‐desazainosin und sein α‐Anomer — Debenzylierung von Thionucleosiden mit Bortrichlorid
Author(s) -
Seela Frank,
Menkhoff Sabine
Publication year - 1982
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198219820422
Subject(s) - chemistry , boron trichloride , anomer , dichloromethane , moiety , pyrimidine , boron , medicinal chemistry , organic chemistry , stereochemistry , solvent
2‐Methylthio‐7‐deazainosine and its α‐Anomer — Debenzylation of Thionucleosides with Boron Trichloride Debenzylation of the sugar moiety of pyrrolo[2,3‐ d ]pyrimidine nucleosides without affecting methoxy or methylthio substituents of the chromophore has been accomplished by the action of boron trichloride/dichloromethane at — 78°C. Applying this method to the protected derivatives 1b or 2b the methylthio nucleosides 3 and 4 were obtained in high yields.