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Eine Synthese 1‐substituierter 5‐Cyanuracile
Author(s) -
Wolfbeis Otto S.
Publication year - 1982
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198219820118
Subject(s) - chemistry , aniline , yield (engineering) , urea , fluorescence , hydrolysis , condensation , medicinal chemistry , organic chemistry , materials science , physics , quantum mechanics , metallurgy , thermodynamics
Synthesis of 1‐Substituted 5‐Cyanouracils Condensation of (cyanoacetyl)urea (1) with aniline and trimethoxymethane affords (3‐anilino‐2‐cyanoacryloyl)urea (2a), which thermally cyclizes to form strongly fluorescent 5‐cyano‐1‐phenyluracil (3a). By using 2‐aminopyridine or trimethoxyethane, other uracils (3b, c) are obtained. 3a–c are hydrolyzed to yield the carboxamides 4a–c. UV and fluorescence data are given for the compounds 3 and 4.