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Kinetic study of the alkaline hydrolysis of 2,2,2‐trichloro‐1‐hydroxyethyl substituted phosphinates and phosphine oxides
Author(s) -
Aksnes Gunnar,
Larsen Rolf Olaf
Publication year - 1981
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198119811105
Subject(s) - chemistry , phosphine , phosphine oxide , hydrolysis , alkaline hydrolysis , medicinal chemistry , organic chemistry , oxide , dichloroacetic acid , catalysis
The study shows that the alkaline hydrolysis of 2,2,2‐trichloro‐1‐hydroxyethyl substituted phosphinates follows the same route as the corresponding phosphonates, Dipterex ( 1 ) and its ethyl analogue, giving O ‐ P ‐ C rearrangement products. The corresponding diphenyl and diethyl phosphine oxide derivatives 7 or 6 , respectively, are hydrolyzed according to another reaction mechanism resulting in secondary phosphine oxides and dichloroacetic acid.