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Synthesis of Isomeric N ‐Benzyl Derivatives of 1,2‐Propanediamine
Author(s) -
Kurganov Alexandr,
Zhuchkova Lydmila,
Davankov Vadim
Publication year - 1980
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198019800518
Subject(s) - chemistry , benzaldehyde , schiff base , base (topology) , group (periodic table) , medicinal chemistry , stereochemistry , organic chemistry , catalysis , mathematics , mathematical analysis
Benzaldehyde reacts with the 1‐amino group of 1,2‐propanediamine (1) to give a Schiff base much more readily than with the 2‐amino group. This difference permits synthesis of all the isomeric mono‐ and dibenzyl derivatives of racemic and chiral 1,2‐propanediamine (Table 1, Scheme 1).