Open AccessNanodelivery strategies for the treatment of multidrug‐resistant bacterial infections
Author(s) -
Jiang Lai,
Lin Jia,
Taggart Clifford C.,
Bengoechea José A.,
Scott Christopher J.
Publication year - 2018
Publication title -
journal of interdisciplinary nanomedicine
Language(s) - English
Resource type - Journals
ISSN - 2058-3273
DOI - 10.1002/jin2.48
Subject(s) - acinetobacter baumannii , enterococcus faecium , pseudomonas aeruginosa , antibiotics , microbiology and biotechnology , multiple drug resistance , antibiotic resistance , staphylococcus aureus , klebsiella pneumoniae , acinetobacter , biology , medicine , bacteria , escherichia coli , biochemistry , genetics , gene
One of the most important health concerns in society is the development of nosocomial infections caused by multidrug‐resistant pathogens. The purpose of this review is to discuss the issues in current antibiotic therapies and the ongoing progress of developing new strategies for the treatment of ESKAPE pathogen infections, which is acronymized for Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , and Enterobacter species. We not only examine the current issues caused by multidrug resistance but we also examine the barrier effects such as biofilm and intracellular localization exploited by these pathogens to avoid antibiotic exposure. Recent innovations in nanomedicine approaches and antibody antibiotic conjugates are reviewed as potential novel approaches for the treatment of bacterial infection, which ultimately may expand the useful life span of current antibiotics.