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Aneuploidy, copy number variation and unique chromosomal structures in bottom‐fermenting yeast revealed by array‐CGH
Author(s) -
Tadami Hideyo,
ShikataMiyoshi Miho,
Ogata Tomoo
Publication year - 2014
Publication title -
journal of the institute of brewing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.523
H-Index - 51
eISSN - 2050-0416
pISSN - 0046-9750
DOI - 10.1002/jib.108
Subject(s) - aneuploidy , yeast , biology , variation (astronomy) , copy number variation , genetics , chromosome , gene , genome , physics , astrophysics
DNA microarray for comparative genome hybridization (CGH) of bottom‐fermenting yeast was performed based on our in‐house DNA sequence data. Aneuploidy, copy number variation and unique chromosomal structures were observed among bottom‐fermenting yeast strains. Our array experiments revealed a correlation between copy number variation and mRNA expression levels. Chromosomal structures in a Saccharomyces carlsbergensis ‐type strain and in a S . monacensis ‐type strain that both belong to S . pastorianus phylogenetically differed greatly from those in contemporary industrial bottom‐fermenting yeast strains. The knowledge gained in this study contributes to a more precise genomic characterization of bottom‐fermenting yeast strains. Copyright © 2014 The Institute of Brewing & Distilling