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Clinical and virologic factors associated with outcomes of COVID‐19 before and after vaccination among Veterans: Retrospective analysis from six New England states
Author(s) -
Lee Megan,
Cosentino Danielle,
Kyriakides Tassos C.,
Cavallaro Tricia,
Stack Gary,
Gupta Shaili
Publication year - 2022
Publication title -
journal of hospital medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.128
H-Index - 65
eISSN - 1553-5606
pISSN - 1553-5592
DOI - 10.1002/jhm.12852
Subject(s) - medicine , vaccination , epidemiology , retrospective cohort study , intensive care unit , covid-19 , health care , young adult , medline , demography , emergency medicine , pediatrics , gerontology , virology , disease , infectious disease (medical specialty) , political science , law , economics , economic growth , sociology
We aimed to characterize clinical and demographic factors affecting clinical outcomes of COVID‐19 and describe viral epidemiology among unvaccinated Veterans in New England. Veterans infected with COVID‐19 in Veterans Administration healthcare systems in six New England states from April 8, 2020, to September 2, 2021, were correlated with outcomes of 30‐day mortality, nonpsychiatric hospitalization, and intensive care unit admission (ICU‐care). We sequenced 827 viral genomes. Of 3950 Veterans with COVID‐19 before full vaccination, 81% were White, 8% were women, and the mean age was 60 years. Overall, 19% of Veterans required hospitalization, 2.8% required ICU care, and 4.9% died. In this largely male and older cohort, poor outcomes correlated with increasing age. Most New England Veterans (>97%) were infected with B.1 sublineages with the D614G mutation in 2020 and early 2021. B.1.617.2 lineage (68%) predominated after July 2021.