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Synthesis and Biological Activity of a Novel Pentacyclic Heterocycle [1][, ]
Author(s) -
Das Biswanath,
Satyakumar Avula,
Ravikanth Bommena,
Rao Bommena Vittal,
Raju Tuniki Venugopal,
Siddhardha Busi,
Murty Upadyayula Suryanaryana
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.982
Subject(s) - chemistry , intramolecular force , antifungal , cycloaddition , stereochemistry , cleavage (geology) , alcohol , biological activity , combinatorial chemistry , d glucose , organic chemistry , in vitro , catalysis , biochemistry , geotechnical engineering , dermatology , fracture (geology) , medicine , engineering
A novel pentacyclic heterocycle has been synthesized starting from D ‐glucose involving two crucial conversions: the intramolecular cycloaddition of O ‐allyloxy furanaldoxime derived from D ‐glucose to furanopyran‐2‐isoxazoline and its diastereoselective reductive cleavage to the corresponding cis ‐1,3‐amino alcohol. The antibacterial and antifungal activities of the synthesized heterocycle have been examined.