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An Eficient One‐Pot Synthesis of 1,4‐Dihydropyridines Catalyzed by Magnetic Nanocrystalline Fe 3 O 4
Author(s) -
Yang ShuHong,
Zhao FeiYang,
Lü HongYan,
Deng Jia,
Zhang ZhanHui
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.953
Subject(s) - nanocrystalline material , chemistry , catalysis , catalytic efficiency , magnet , component (thermodynamics) , reaction conditions , organic chemistry , combinatorial chemistry , crystallography , physics , quantum mechanics , thermodynamics
An efficient approach for one‐pot three‐component reaction of aromatic amines, α,β‐unsaturated aldehydes and β‐keto esters using magnetic nanocrystalline Fe 3 O 4 as a catalyst has been described. The corresponding 1,4‐dihydropyridines are obtained in good yields under mild conditions. In addition, the catalyst can be recovered with a magnet and reused at least five consecutive cycles without appreciable loss of its catalytic activity .