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Rapid and Efficient Microwave‐Assisted Synthesis of Some New Triazol‐3‐one Derivatives
Author(s) -
Menteşe Emre,
Özil Musa,
Karaoğlu Şengül Alpay,
Kahveci Bahittin
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.946
Subject(s) - chemistry , microwave , microwave irradiation , acetylation , combinatorial chemistry , microwave heating , antimicrobial , nuclear chemistry , nanotechnology , organic chemistry , catalysis , biochemistry , materials science , physics , quantum mechanics , gene
A growing body of literature has shown the effectiveness of using microwaves in chemical reactions. The aim of this study is to demonstrate a rapid and highly efficient synthesis of some new triazol‐3‐ones via microwave heating using a monomode microwave. Compared with the thermal process, the microwave heating induces a dramatic reduction of the reaction time and improvement of the yields. In this study, rapid N ‐benzylation and N ‐acetylation of triazol‐3‐ones were achieved by microwave irradiation method for the first time. The newly synthesized compounds showed moderate antimicrobial activity against the standard bacterial and fungal organisms tested.