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Synthesis, Characterization, and In Vitro Antibacterial Activities of Macromolecules Derived from Bis‐Chalcone
Author(s) -
Asiri Abdullah M.,
Khan Salman A.
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.942
Subject(s) - chemistry , chalcone , thiourea , antibacterial activity , macromolecule , chloramphenicol , guanidine , pyrazoline , in vitro , minimum inhibitory concentration , nuclear chemistry , proton nmr , hydrochloride , antibacterial agent , combinatorial chemistry , stereochemistry , organic chemistry , bacteria , antibiotics , biochemistry , biology , genetics
We investigated the antibacterial activity of some new macromolecules such as bis‐pyrazoline, bis‐pyrazole, bis‐pyrimidines prepared from the reaction of bis‐chalcone with thiosemicarbazide/phenyl hydrazine/guanidine hydrochloride/thiourea. All the macromolecules have been characterized by IR, 1 H NMR, 13 C NMR, mass and elemental analyses. The antibacterial activity of these compounds was first tested in vitro by the disc diffusion assay against two Gram‐positive and two Gram‐negative bacteria, and then the minimum inhibitory concentration was determined with the reference to standard drug chloramphenicol. The results showed that pyrazoline derivative showed better antibacterial activity on S. typhimurium and E. coli than the reference drug chloramphenicol.