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A Simple and Convenient Synthesis of 4‐Ylidene‐5(4 H )oxazolone Derivatives: Oxazolone Ring Transformation Leading to Other Heterocyclic Structures
Author(s) -
AbdelMotaleb Ramadan M.,
Bakeer Hadeer M.,
Tamam Gammal H.,
Arafa Wael A. A.
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.938
Subject(s) - oxazolone , chemistry , ring (chemistry) , yield (engineering) , anhydrous , sodium methoxide , pyridazine , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry , catalysis , materials science , metallurgy
Simple, effective, and high yield synthetic procedure for the synthesis of 4‐ylidene‐5(4 H )‐oxazolones 2a–m from arylidene‐malononitriles under solvent‐free conditions is described. The scope of this reaction was investigated, and it was found that the presence of anhydrous sodium acetate gave the corresponding oxazolones in excellent yields. The newly generated oxazolone derivative 2m underwent ring transformation into pyrroles, imidazoles, pyridazine, and triazines.