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Synthesis and Biological Activity of Some New Pyrazole Copper(II) Complexes
Author(s) -
Maruoka Hiroshi,
Nishida Sho,
Kashige Nobuhiro,
Yoshimura Yuki,
Omori Masahiko,
Tomita Ryoko,
Masumoto Eiichi,
Okabe Fumi,
Miake Fumio,
Yamagata Kenji,
Fujioka Toshihiro
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.919
Subject(s) - chemistry , pyrazole , hela , copper , sodium hydride , biological activity , in vitro , stereochemistry , medicinal chemistry , organic chemistry , biochemistry
As a part of systematic investigation of synthesis and biologically active compounds of pyrazole derivatives containing transition metal, several new pyrazole copper(II) complexes 3a−f were synthesized from pyrazole sodium salts 2a−f , which were produced from spiro‐pyrazoles 1a−f and sodium hydride by a ring‐opening reaction. All the synthesized compounds were characterized by spectroscopic analysis. Pyrazole copper(II) complexes 3a−d and 3f exhibited high DNA cleavage activity in vitro . Furthermore, compounds 3a−f were tested for their growth inhibitory activity in A549 lung cancer, B16F10 murine melanoma, and HeLa human uterine carcinoma cells. Compounds 3c,d displayed moderate B16F10 and HeLa inhibitory activity levels ( 3c : IC 50 = 45 μ M in B16F10 cells and 34 μ M in HeLa cells, 3d : IC 50 = 50 μ M in B16F10 cells and 32 μ M in HeLa cells).