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Solvent‐Free Synthesis of 2‐(Phenylamino)‐4‐(trifluoromethyl)‐1,6‐dihydropyrimidine Derivatives Catalyzed by Sulfamic Acid
Author(s) -
Shen Shide,
Yang Weihua,
Yu Chenxia,
Li Tuanjie,
Yao Changsheng
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.912
Subject(s) - chemistry , sulfamic acid , aldehyde , trifluoromethyl , catalysis , organic chemistry , solvent , aryl , alkyl
A series of 2‐(phenylamino)‐4‐(trifluoromethyl)‐1,6‐dihydropyrimidine derivatives were synthesized efficienly via the reaction of aryl aldehyde, ethyl 4,4,4‐trifluoro‐3‐oxobutanoate and 1‐phenylguanidine carbonate catalyzed by sulfamic acid under solvent‐free conditions. This protocol has the advantages of mild condition, high yields and environmentally benign procedure.