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Synthesis and Antimicrobial Activity of New Thiazole Derivatives and Their Glucoside and Acyclic Nucleoside Analogs
Author(s) -
Ali Omar M.,
ElSayed Wael A.,
ElSayed Heba A.,
AbdelRahman Adel A.H.
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.900
Subject(s) - chemistry , thiazole , bacillus subtilis , antimicrobial , candida albicans , staphylococcus aureus , escherichia coli , nucleoside , stereochemistry , glucoside , organic chemistry , bacteria , biochemistry , microbiology and biotechnology , genetics , gene , biology , medicine , alternative medicine , pathology
New thiazole derivatives were synthesized. The N ‐substituted acyclic nucleoside analogs and the substituted glucosides were also prepared. The synthesized compounds were tested for their antimicrobial activity against Candida albicans , Escherichia coli , Staphylococcus aureus , and Bacillus subtilis . The obtained results indicated that most of the tested compounds exhibited low to high moderate activities whereas few compounds were found to exhibit little or no activity against the tested microorganisms.