The Utility of Carbon Disulphide and Lawesson's Reagent for Synthesis of Different Fused Heterocycles for Antimicrobial Evaluation

Hexahydroquinolines 1a , 1b reacted with carbon disulphide in different conditions to yield the corresponding adducts 2a , 2b and 3a , 3b . Carrying out the same reactions in acetone as solvent produced the modified new products 4a , 4b . The interaction of pyrazolopyridine derivatives 5a , 5b , 5c , 5d with carbon disulphide under the same previous conditions furnished the isolated products 6a , 6b , 6c , 6d , 7a , 7b , 7c , 7d , and 8a , 8b , 8c , 8d . Studying the behavior of 1a , 1b or 5a , 5b , 5c , 5d toward Lawesson's reagent (LR) formed the final adducts 11a , 11b or 12a , 12b , 12c , 12d . The structure of synthesized compounds was confirmed with the spectroscopic and microanalytical data. The biological activities of 2a , 4a , 4b , 7a , 7c , 8d , 11a , 11b , 12b , and 12c were tested for antimicrobial evaluation.