Synthesis of Novel 5,6‐Dihydropyrrolo[2,1‐ a ]isoquinolines  via  Grob Reaction between ( E )‐1,1,1‐Trifluoro‐3‐nitro‐2‐butene and 3,4‐Dihydroisoquinolines | Zendy

Korotaev Vladislav Y. | Zendy; Sosnovskikh Vyacheslav Y. | Zendy; Barkov Alexey Y. | Zendy; Slepukhin Pavel A. | Zendy; Shklyaev Yurii V. | Zendy

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Synthesis of Novel 5,6‐Dihydropyrrolo[2,1‐ a ]isoquinolines via Grob Reaction between ( E )‐1,1,1‐Trifluoro‐3‐nitro‐2‐butene and 3,4‐Dihydroisoquinolines

Author(s) -

Korotaev Vladislav Y.,

Sosnovskikh Vyacheslav Y.,

Barkov Alexey Y.,

Slepukhin Pavel A.,

Shklyaev Yurii V.

Publication year - 2012

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.881

Subject(s) - chemistry , nitro , 2 butene , cycloaddition , medicinal chemistry , stereochemistry , organic chemistry , catalysis , alkyl

Uncatalyzed cycloaddition of 3,4‐dihydroisoquinolines to ( E )‐1,1,1‐trifluoro‐3‐nitro‐2‐butene via Grob reaction provide a simple one‐step route to the 5,6‐dihydropyrrolo[2,1‐ a ]isoquinolines, which represent the basic structural framework of the antitumor active alkaloid crispine.

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