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Synthesis of Novel 5,6‐Dihydropyrrolo[2,1‐ a ]isoquinolines via Grob Reaction between ( E )‐1,1,1‐Trifluoro‐3‐nitro‐2‐butene and 3,4‐Dihydroisoquinolines
Author(s) -
Korotaev Vladislav Y.,
Sosnovskikh Vyacheslav Y.,
Barkov Alexey Y.,
Slepukhin Pavel A.,
Shklyaev Yurii V.
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.881
Subject(s) - chemistry , nitro , 2 butene , cycloaddition , medicinal chemistry , stereochemistry , organic chemistry , catalysis , alkyl
Uncatalyzed cycloaddition of 3,4‐dihydroisoquinolines to ( E )‐1,1,1‐trifluoro‐3‐nitro‐2‐butene via Grob reaction provide a simple one‐step route to the 5,6‐dihydropyrrolo[2,1‐ a ]isoquinolines, which represent the basic structural framework of the antitumor active alkaloid crispine.