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Facile Synthesis of 3,6‐Disubstituted‐1,2,4‐triazolo‐[3,4‐ b ]‐1,3,4‐thiadiazoles via Oxidative Cyclization of n ‐Heteroaryl‐Substituted Hydrazones and Their Biological Activity
Author(s) -
Himaja M.,
Prathap K. Jagadeesh,
Mali Sunil V.
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.870
Subject(s) - chemistry , thiadiazoles , chloramine t , yield (engineering) , oxidative phosphorylation , antioxidant , biological activity , proton nmr , medicinal chemistry , organic chemistry , combinatorial chemistry , in vitro , biochemistry , materials science , metallurgy
Fused 3,6‐disubstituted triazolothiadiazoles were synthesized in good yield from a rapid and convenient oxidative cyclization of N ‐heteroaryl‐substituted hydrazones promoted by chloramine‐T trihydrate at ambient temperature. The structure of the synthesized compounds was confirmed by FTIR, 1 H NMR, 13 C NMR, and mass spectral data. The synthesized compounds were evaluated for their antioxidant and antitubercular activities. All the compounds 5a‐i and 6a‐i showed good antitubercular activity. However, only compounds 5a‐i showed good antioxidant activity.