z-logo
Premium
Benzimidazole Annulated New Heterocyclic Compounds: Synthesis of New Polycyclic Pyrazole Derivatives
Author(s) -
Khalil Mohamed Ali A.
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.867
Subject(s) - chemistry , pyrazole , acetonitrile , benzimidazole , pyrazine , reagent , pyrimidine , combinatorial chemistry , azepine , nucleophilic addition , nucleophile , organic chemistry , medicinal chemistry , stereochemistry , catalysis
Several ( 3 ) new benzimidazole based polycyclic compounds of potential pharmaceutical interest have been prepared starting from 2‐benzimidazolelyl (1,3‐dioxo‐2‐indenylidene) acetonitrile. Unhypothesized, the C≡N function of the plausible intermediates was released as HCN rather than a classical nucleophilic addition when treated with bidentate reagents such as hydrazines, 5‐amino‐1 H ‐1,2,4‐triazole, 5‐amino‐4‐cyano‐1 H ‐pyrazole and 2‐aminobenzimidazole. When compound 3 reacted with active acetonitrile derivatives it afforded new polyfunctional pyridines via elimination of HCN in addition to, new pyrimidine, pyrazine and azepine derivatives.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here