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Synthesis of New PMB‐Substituted Indoles Containing 1,3,4‐Oxadiazole and 1,2,4‐Triazole Units
Author(s) -
Farghaly AbdelRahman,
Haider Norbert,
Lee DuckHyung
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.864
Subject(s) - chemistry , oxadiazole , indole test , carbohydrazide , 1,2,4 triazole , triazole , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry
A series of new indolyl‐1,3,4‐oxadiazole derivatives 3 , 4 , 5 , 6 , 7 and 10 , indolyl‐1,2,4‐triazole derivatives 14 and 15 was prepared, using 1‐(4‐methoxybenzyl)‐1 H ‐indole‐3‐carbohydrazide ( 2 ) as a key intermediate. Some of the new compounds were evaluated for their antineoplastic activity.