An efficient one‐pot synthesis of pyrimido[2,1‐b][1,3]oxazine derivatives  via  the reaction of isocyanides with dialkyl acetylenedicarboxylates in the presence of 5‐substituted uracils | Zendy

Baharfar Robabeh | Zendy; Baghbanian Seyed Meysam | Zendy

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An efficient one‐pot synthesis of pyrimido[2,1‐b][1,3]oxazine derivatives via the reaction of isocyanides with dialkyl acetylenedicarboxylates in the presence of 5‐substituted uracils

Author(s) -

Baharfar Robabeh,

Baghbanian Seyed Meysam

Publication year - 2012

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.863

Subject(s) - chemistry , yield (engineering) , uracil , alkyl , medicinal chemistry , reactive intermediate , combinatorial chemistry , organic chemistry , catalysis , dna , biochemistry , materials science , metallurgy

The reactive 1:1 intermediate produced in the reaction between alkyl isocyanides and dialkyl acetylenedicarboxylates was trapped by uracil and its 5‐substituted derivatives to yield highly functionalized pyrimido[2,1‐b][1,3]oxazine derivatives in fairly good yields. J. Heterocyclic Chem.,(2011).

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