Premium
Chemoselectivity of 2‐Arylmethyleneaminoisoindolin‐1,3‐diones toward Arenes under Friedel–Crafts Conditions: An Efficient Synthesis of Benzophenones Integrated with 2‐Substituted Hydrazone Moieties
Author(s) -
Derbala Hamed A.
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.854
Subject(s) - chemistry , chemoselectivity , hydrazone , friedel–crafts reaction , aryl , proton nmr , organic chemistry , catalysis , mass spectrum , carbon 13 nmr , medicinal chemistry , ion , alkyl
Treatment 2‐arylmethyleneaminoisoindole‐1,3‐diones 1a – c with arenes in the presence of AlCl 3 ‐DMF complex as a catalyst afforded the novel compounds, 2‐((arylidenehydrazono)(aryl)‐methyl)benzophenones 3a – n in satisfactory yields. The structure of the obtained products 3a – n was confirmed by the use of IR, 1 H‐NMR, 13 C‐NMR, mass spectra, and elemental analyses.