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General Two‐Step Preparation of Chalcones Containing Thiazole
Author(s) -
Tazoo Dagobert,
Oniga Ovidiu,
Bohle D. Scott,
Chua Zhijie,
Dongo Etienne
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.853
Subject(s) - chemistry , thiazole , aryl , proton nmr , carbon 13 nmr , mass spectrometry , crystal structure , organic chemistry , chalcone , chromatography , alkyl
2‐Aryl‐4‐methyl‐5‐acetylthiazoles, which were prepared from arylthioamides and chloroacetylacetone, were treated with 6‐substituted‐3‐formylchromones or arylaldehydes to give a series of eighteen new thiazolylchalcones in good yields. The structures of all the synthesized compounds were characterized by 1 H NMR, 13 C NMR, and ES‐MS spectrometry. Additionally, the crystal structures of two of these chalcones were determined by X‐ray diffraction analysis.