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Synthesis of Some Novel Pyrazole‐Substituted 9‐Anilinoacridine Derivatives and Evaluation for their Antioxidant and Cytotoxic Activities
Author(s) -
Kalirajan R.,
Muralidharan V.,
Jubie S.,
Gowramma B.,
Gomathy S.,
Sankar S.,
Elango K.
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.848
Subject(s) - chemistry , pyrazole , antioxidant , cytotoxic t cell , in vitro , combinatorial chemistry , cytotoxicity , cell culture , stereochemistry , organic chemistry , biochemistry , biology , genetics
This article focuses on the synthesis of new series of pyrazole‐substituted 9‐anilinoacridine derivatives 5a – m and 6a – l . The compounds were confirmed by physical and analytical data. The synthesized compounds when screened for in vitro antioxidant activity showed promising activity for many compounds. The selected compounds were screened for cytotoxic activity showed promising inhibition of HEp‐2 cell line for the compounds 6c , 6e , and 6f .