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Synthesis of 1,2,4,5‐Tetrasubstituted Imidazoles Using Sulfuric Acid ([3‐(3‐Silicapropyl)sulfanyl]propyl]ester as a Recyclable Solid Acid
Author(s) -
Tavakoli Ziba,
Bagherneghad Mojtaba,
Niknam Khodabakhsh
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.847
Subject(s) - chemistry , benzil , sulfanyl , ammonium acetate , sulfuric acid , catalysis , organic chemistry , amine gas treating , condensation , physics , high performance liquid chromatography , thermodynamics
Sulfuric acid ([3‐(3‐silicapropyl)sulfanyl]propyl]ester (SASPSPE) is used as a recyclable catalyst for the synthesis of 1,2,4,5‐tetrasubstituted imidazoles. A range of various polysubstituted imidazoles was synthesized via four‐component condensation of benzil, aldehydes, amines, and ammonium acetate in the presence of SASPSPE under solvent‐free conditions at 140°C. The heterogeneous catalyst was recycled for five runs on the reaction of benzil, 4‐methylbenzaldehyde, benzyl amine, and ammonium acetate without losing its catalytic activity.