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Polycyclic N ‐Heterocyclic Compounds, Part 71: Synthesis and Bronchodilator Evaluation of 5‐Substituted 1,2‐Dihydrofuro[3,2‐ f ][1,7]naphthyridines and Related Compounds
Author(s) -
Okuda Kensuke,
Matsushita Tetsuo,
Hirota Takashi,
Sasaki Kenji
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.846
Subject(s) - chemistry , bronchodilator , potency , chloride , stereochemistry , bronchodilator agents , combinatorial chemistry , medicinal chemistry , organic chemistry , biochemistry , in vitro , asthma , medicine
Several 5‐substituted 1,2‐dihydrofuro[3,2‐ f ][1,7]naphthyridines were synthesized as part of our research to develop new effective bronchodilators. Amines, sulfanyls, and alcohols were used as substituents at the fifth position. Tetracyclic compounds were also obtained. Evaluation of the effects of the newly synthesized compounds on carbamoylcholine chloride‐induced contractions of trachea revealed one promising bronchodilator candidate with potency comparable to that of 3‐isobutyl‐1‐methylxanthine.