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An Efficient Synthesis of 4‐Naphthylpyrimidin‐2‐amine Derivatives under Solvent‐Free Conditions
Author(s) -
Rong Liangce,
Ji Honglou,
Xia Sheng,
Yin Shan,
Shi Yanhui,
Tu Shujiang
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.839
Subject(s) - chemistry , amine gas treating , guanidine , solvent , sodium hydroxide , organic chemistry , sodium carbonate , aromatic amine , reaction conditions , combinatorial chemistry , sodium , catalysis
A simple, efficient, and mild protocol for the synthesis of 4‐naphthylpyrimidin‐2‐amine derivatives under solvent‐free conditions by the reaction of aromatic aldehydes (or 1‐naphthaldehyde), 2‐acetylnaphthalene (or aromatic ketones), guanidine carbonate, and sodium hydroxide was reported. The advantages of this protocol include short reaction time, mild reaction conditions, easy workup, high yields, and environmental friendliness.