Three‐Component Domino Reaction in PPG: An Easy Access to 4‐Thiazolidinone Derivatives | Zendy

Prasad Davinder | Zendy; Nath Mahendra | Zendy

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Three‐Component Domino Reaction in PPG: An Easy Access to 4‐Thiazolidinone Derivatives

Author(s) -

Prasad Davinder,

Nath Mahendra

Publication year - 2012

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.838

Subject(s) - chemistry , thioglycolic acid , cyclohexanone , domino , organic chemistry , polypropylene glycol , component (thermodynamics) , malononitrile , condensation , solvent , condensation reaction , catalysis , knoevenagel condensation , combinatorial chemistry , polyethylene glycol , physics , thermodynamics

A simple, economical, and convenient synthesis of a new series of 4‐thiazolidinone derivatives using one‐pot three‐component condensation of aromatic amines, thioglycolic acid and aromatic aldehydes or cyclohexanone in polypropylene glycol (PPG), a recyclable and inexpensive solvent medium is reported. All the reactions are carried out at 110°C without using catalyst or additives. The products are obtained in good to excellent yields (60–97%) after easy workup and purification.

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