Premium
Three‐Component Domino Reaction in PPG: An Easy Access to 4‐Thiazolidinone Derivatives
Author(s) -
Prasad Davinder,
Nath Mahendra
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.838
Subject(s) - chemistry , thioglycolic acid , cyclohexanone , domino , organic chemistry , polypropylene glycol , component (thermodynamics) , malononitrile , condensation , solvent , condensation reaction , catalysis , knoevenagel condensation , combinatorial chemistry , polyethylene glycol , physics , thermodynamics
A simple, economical, and convenient synthesis of a new series of 4‐thiazolidinone derivatives using one‐pot three‐component condensation of aromatic amines, thioglycolic acid and aromatic aldehydes or cyclohexanone in polypropylene glycol (PPG), a recyclable and inexpensive solvent medium is reported. All the reactions are carried out at 110°C without using catalyst or additives. The products are obtained in good to excellent yields (60–97%) after easy workup and purification.