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Expeditious Synthesis and Single Crystal Structure of New Pyrazole‐Fused 1,4‐Oxazine
Author(s) -
Zheng LiangWen,
Zhao BaoXiang,
Liu YingRui
Publication year - 2012
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.833
Subject(s) - chemistry , pyrazole , crystallization , crystal structure , single crystal , crystal (programming language) , molecule , stereochemistry , combinatorial chemistry , crystallography , organic chemistry , computer science , programming language
A series of 2,6‐diphenyl‐4 H ‐pyrazolo[5,1‐ c ][1,4]oxazin‐4‐ones has been synthesized via a lactonization of 1‐(2‐oxo‐2‐phenylethyl)‐3‐phenyl‐1 H ‐pyrazole‐5‐carboxylic acids in the presence of Ac 2 O at reflux temperature. The products were isolated by simple filtration in excellent yields and were characterized by IR, 1 H‐NMR, and HRMS. The molecular structure was confirmed by the X‐ray crystal analysis of one compound that was prone to crystallization.